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Abstract #2397

In Vivo Detection of Omega-3 Fatty Acids at 7 T with MEGA-sLASER

Lukas Hingerl1, Martin Gajdošík1, Michal Považan1, Bernhard Strasser1, Gilbert Hangel1, Martin Krššák1, Siegfried Trattnig1,2, and Wolfgang Bogner1

1High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 2Christian Doppler Laboratory for Clinical Molecular MR Imaging, Medical University of Vienna, Vienna, Austria

We present a method for detecting omega-3 fatty acids (FA) at 7 T by 1H-MR spectroscopy (MRS) using a MEGA-sLASER editing sequence with 12 kHz AFP GOIA-WURST(16,4) pulses for localization. sLASER localization offers reduced sensitivity to B1 inhomogeneities, lowers pulse power requirements compared to PRESS or STEAM and the localization pulses substantially reduce the 4-compartment effect. The spectra of in vivo measurements at the echo times TE=332 ms ,465.4 ms and 1130 ms show the omega-3 signal very well.

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