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Abstract #2398

Cerebral Acetate Transport and Utilization in the Rat Brain in vivo using 1H MRS: Consequences of a revised acetate volume of distribution value

Masoumeh Dehghani M.1, Bernard Lanz1, Nicolas Kunz2, Pascal mieville3, and Rolf Gruetter1,2,4,5

1Laboratoire d'imagerie fonctionnelle et métabolique(LIFMET), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 2Centre d’Imagerie Biomedicale(CIBM), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 3Institute of Chemical Sciences and Engineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 4Department of Radiology, University of Lausanne, Lausanne, Switzerland, 5Department of Radiology, University of Geneva, Geneva, Switzerland

Metabolic modeling of metabolite 13C turnover curves in brain with 13C-labeled acetate infused as tracer substrate requires prior knowledge of the transport and uptake kinetics of Ace. The aim of this study was to determine the kinetics of transport and utilization for acetate uptake in the rat brain using specific distribution volume of Ace(Vd) in the rat brain. The dependency of estimated CMRace to distribution volume of Ace in the rat brain highlights the importance about a refined determination of Vd for Ace in brain metabolic studies.

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