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Abstract #2399

Interleaved measurements of BOLD response and energy metabolism in exercising human calf muscle

Adrianus J. Bakermans1, Chang Ho Wessel2, Paul F.C. Groot1, Erik S.G. Stroes2, and Aart J. Nederveen1

1Department of Radiology, Academic Medical Center, Amsterdam, Netherlands, 2Department of Vascular Medicine, Academic Medical Center, Amsterdam, Netherlands

Typically, dynamic MR studies of exercising skeletal muscle are limited to measurements of only one parameter. Obtaining multiple parameters simultaneously during a single experiment would provide more insight into (patho-)physiology. Here, we report on interleaved acquisitions of quantitative T2* maps for assessments of the BOLD response, and 31P-MR spectra for measuring phosphocreatine recovery kinetics during an exercise-recovery protocol in healthy subjects and peripheral artery disease (PAD) patients. We demonstrate that with such interleaved acquisitions, it is feasible to dynamically assess both tissue oxygenation as well as muscle energy metabolism in the human calf muscle during a single exercise session.

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