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Abstract #2407

Region-specific Neurochemical profile differences in juvenile rat model for ADHD and control strain: a 1H MRS study @ 11.7T

Alireza Abaei1, Francesca Rizzo2, Dinesh K Deelchand3, Anne Subgang1, Johannes T. Schneider4, Andrea G. Ludolph5, and Volker Rasche1,6

1Medical Faculty, Core Facility Small Animal MRI, Ulm University, Ulm, Germany, 2Institute of Anatomy and Cell Biology, University of Ulm, Ulm, Germany, 3University of Minnesota, Minneapolis, MN, United States, 4Bruker BioSpin MRI GmbH, Ettlingen, Germany, 5Department of Child and Adolescent Psychiatry, University of Ulm, Ulm, Germany, 6Department of Internal Medicine II, University Hospital Ulm, Ulm, Germany

Assessment and reliable quantification of brain metabolites is of great interest for diagnosis and monitoring of neurodegenerative psychiatric disorders. Challenging in this context is the required spectral fidelity demanding a combination of rapid data acquisition, optimal frequency and phase correction, and excellent shimming of the volume of interest. In this contribution, an optimized STEAM sequence was combined with image-based shimming and single-shot frequency and phase correction. The method was applied to assessment of the difference between the metabolic profile of spontaneous hypertensive rats and Wistar-Kyoto rats. Statistically significant differences could be quantified in the striatum and the prefrontal cortex.

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