Proton MR Metabolic Profiling in combination with serum procalcitonin levels as rapid indicators for differentiation of Urosepsis
Suruchi Singh1, Tanushri Chatterji2, Manodeep Sen2, Ishwar Ram3, and Raja Roy1
1Centre of Biomedical Research, Lucknow, India, 2Department of Microbiology, Dr Ram Manohar Lohia Institute of Medical Sciences, Lucknow, India, 3Department of Urology, Dr Ram Manohar Lohia Institute of Medical Sciences, Lucknow, India
This study is a new approach for the
diagnosis of Urosepsis using Proton MR spectroscopy along with serum
procalcitonin levels. The study insights, NMR based metabolic profiling for
differentiation of Urosepsis, a medical emergency which requires immediate
patient care. The analysis takes less than one hour for disease identification,
thus enabling quick and efficient patient management. The Principal Component
Analysis (PCA) displayed that glucose and lactate in serum were the major
confounders in differentiating Urosepsis cases from Healthy controls. The
training set of Partial least square Discriminant analysis (PLS-DA) provided
precise prediction of the test set in serum samples.
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