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Abstract #2411

Proton MR Metabolic Profiling in combination with serum procalcitonin levels as rapid indicators for differentiation of Urosepsis

Suruchi Singh1, Tanushri Chatterji2, Manodeep Sen2, Ishwar Ram3, and Raja Roy1

1Centre of Biomedical Research, Lucknow, India, 2Department of Microbiology, Dr Ram Manohar Lohia Institute of Medical Sciences, Lucknow, India, 3Department of Urology, Dr Ram Manohar Lohia Institute of Medical Sciences, Lucknow, India

This study is a new approach for the diagnosis of Urosepsis using Proton MR spectroscopy along with serum procalcitonin levels. The study insights, NMR based metabolic profiling for differentiation of Urosepsis, a medical emergency which requires immediate patient care. The analysis takes less than one hour for disease identification, thus enabling quick and efficient patient management. The Principal Component Analysis (PCA) displayed that glucose and lactate in serum were the major confounders in differentiating Urosepsis cases from Healthy controls. The training set of Partial least square Discriminant analysis (PLS-DA) provided precise prediction of the test set in serum samples.

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