Abstract #2410

Intratumoral Agreement of HR-MAS MR spectroscopic profiles in the Metabolic Characterization of Breast Cancer

Vivian Youngjean Park¹, Dahye Yoon², Ja Seung Koo¹, Eun-Kyung Kim³, Seung Il Kim⁴, Ji Soo Choi¹, Suhkmann Kim⁵, and Min Jung Kim¹

¹Yonsei University College of Medicine, Seoul, Korea, Republic of, ²2Department of Chemistry and Chemistry Institute for Functional Materials, Pusan National University, Busan, Korea, Republic of, ³Radiology, Yonsei University College of Medicine, Seoul, Korea, Republic of, ⁴Surgery, Yonsei University College of Medicine, Seoul, Korea, Republic of, ⁵Pusan National University, Busan, Korea, Republic of

We investigated whether intratumoral location and biospecimen type affect the metabolic characterization of breast cancer assessed by HR-MAS MR spectroscopy. This prospective study included 87 tumor tissue samples in 31 patients with invasive breast cancer, obtained from the center and periphery of surgical specimens and preoperatively by CNB. Specimens were assessed with HR-MAS MR spectroscopy. Overall, intratumoral location and biospecimen type had limited influence on the metabolic characterization of breast cancer assessed by HR-MAS MR spectroscopy. However, some metabolites are differentially expressed and caution is recommended in clinical decision-making based solely on metabolite concentrations, especially PC and PE.

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