Abstract #2409

Investigation of Glucose-phosphates in Skeletal Muscle Biopsies by 1H HR-MAS NMR: Comparison between Active and Sedentary Subjects

Gaëlle Diserens¹, Martina Vermathen², Nicholas T. Broskey³, Chris Boesch¹, Francesca Amati^1,3, and Peter Vermathen¹

¹Depts Clinical Research and Radiology, University of Bern, Bern, Switzerland, ²Dept. Chemistry & Biochemistry, University of Bern, Bern, Switzerland, ³Dept. of Physiology, University of Lausanne, Lausanne, Switzerland

The aim of this ¹H HR-MAS NMR study was to investigate biopsies of skeletal muscles comparing athletes, sedentary slim and sedentary obese subjects. ¹H HR-MAS allows the direct assessment of glucose-phosphates contained in skeletal muscle biopsies, as was also previously shown. The current study is the first example for a potential application, demonstrating differences in glucose-phosphates between muscle tissues from athletes and sedentary subjects. The results suggest that quantitative assessment by ¹H HR-MAS NMR of Glc-1P and Glc-6P being key players in energy metabolism may prove important for metabolic studies in biopsies.

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