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Abstract #2409

Investigation of Glucose-phosphates in Skeletal Muscle Biopsies by 1H HR-MAS NMR: Comparison between Active and Sedentary Subjects

Gaƫlle Diserens1, Martina Vermathen2, Nicholas T. Broskey3, Chris Boesch1, Francesca Amati1,3, and Peter Vermathen1

1Depts Clinical Research and Radiology, University of Bern, Bern, Switzerland, 2Dept. Chemistry & Biochemistry, University of Bern, Bern, Switzerland, 3Dept. of Physiology, University of Lausanne, Lausanne, Switzerland

The aim of this 1H HR-MAS NMR study was to investigate biopsies of skeletal muscles comparing athletes, sedentary slim and sedentary obese subjects. 1H HR-MAS allows the direct assessment of glucose-phosphates contained in skeletal muscle biopsies, as was also previously shown. The current study is the first example for a potential application, demonstrating differences in glucose-phosphates between muscle tissues from athletes and sedentary subjects. The results suggest that quantitative assessment by 1H HR-MAS NMR of Glc-1P and Glc-6P being key players in energy metabolism may prove important for metabolic studies in biopsies.

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