Investigation of Glucose-phosphates in Skeletal Muscle Biopsies by 1H HR-MAS NMR: Comparison between Active and Sedentary Subjects
Gaëlle Diserens1, Martina Vermathen2, Nicholas T. Broskey3, Chris Boesch1, Francesca Amati1,3, and Peter Vermathen1
1Depts Clinical Research and Radiology, University of Bern, Bern, Switzerland, 2Dept. Chemistry & Biochemistry, University of Bern, Bern, Switzerland, 3Dept. of Physiology, University of Lausanne, Lausanne, Switzerland
The
aim of this 1H HR-MAS NMR study was to investigate biopsies of skeletal
muscles comparing athletes, sedentary slim and sedentary obese subjects.
1H HR-MAS allows the direct assessment
of glucose-phosphates contained in skeletal muscle biopsies, as was also previously
shown. The current study is the first example for a potential application,
demonstrating differences in glucose-phosphates between muscle tissues from
athletes and sedentary subjects. The results suggest that quantitative
assessment by 1H HR-MAS NMR of Glc-1P and Glc-6P being key players in energy metabolism may prove important for metabolic studies in biopsies.
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