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Abstract #2418

NMR-based Metabolomic Study of Serum in Diabetic Retinopathy

Virendra Kumar1, Tanmoy Bagui2, Rashmi Mukherjee2, Vertika Rai2, Pawan Kumar1, and Chandan Chakraborty2

1Department of NMR, All India Institute of Medical Sciences, New Delhi, India, 2School of Medical Science & Technology, Indian Institute of Technology Kharagpur, Kharagpur, India

Diabetic retinopathy (DR), is a major cause of blindness, caused by prolonged diabetes. However, this morbidity is largely preventable and treatable. The progression of DR from prolonged diabetes involves complex metabolic de-regulations. 1H NMR-based metabolomics of serum have potential to study dysregulation in metabolites of DR patients. Results of the PCA and PLS-DA analysis revealed metabolic differences in DR patients compared to healthy subjects. Using such a study, we may observe the severity of disease based on metabolic fingerprints and it may serve as a platform for screening of molecular targets for a more efficient therapeutic intervention.

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