Abstract #2418

NMR-based Metabolomic Study of Serum in Diabetic Retinopathy

Virendra Kumar¹, Tanmoy Bagui², Rashmi Mukherjee², Vertika Rai², Pawan Kumar¹, and Chandan Chakraborty²

¹Department of NMR, All India Institute of Medical Sciences, New Delhi, India, ²School of Medical Science & Technology, Indian Institute of Technology Kharagpur, Kharagpur, India

Diabetic retinopathy (DR), is a major cause of blindness, caused by prolonged diabetes. However, this morbidity is largely preventable and treatable. The progression of DR from prolonged diabetes involves complex metabolic de-regulations. ¹H NMR-based metabolomics of serum have potential to study dysregulation in metabolites of DR patients. Results of the PCA and PLS-DA analysis revealed metabolic differences in DR patients compared to healthy subjects. Using such a study, we may observe the severity of disease based on metabolic fingerprints and it may serve as a platform for screening of molecular targets for a more efficient therapeutic intervention.

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