Abstract #2419

Acute Spinal Cord Injury (ASCI) Metabolomics Through 1H-NMR Spectroscopy: Metabolic alterations with time & treatment

Alka Singh¹, Suruchi Singh², Saloni Raj¹, Ravindra Kumar Garg³, Abbas Ali Mahdi⁴, Raja Roy², and Rajeshwar Nath Srivastava¹

¹Orthopaedic Surgery, King George's Medical University, Lucknow, India, ²Centre of Biomedical Research, Lucknow, India, ³Neurology, King George's Medical University, Lucknow, India, ⁴Biochemistry, King George's Medical University, Lucknow, India

It mainly focuses on finding significant metabolites in serum using 1H NMR based spectroscopic methods and to study the variation of concentration of these metabolites during the recovery of the patient ongoing treatment after surgery. Significant metabolites, namely, lactate, glycine, acetone and succinate were identified using statistical methods (ANOVA along with Mann- Whitney U test) and are found to be elevated during the time of injury. The levels gradually decrease as the patient recovers in an average period of six months.This is a prospective case-control preliminary study on recovery of the patient during acute spinal cord injury.

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