Abstract #2425

Imaging response to 90-yttrium radioembolization with volumetric ADC DWI in patients with metastatic liver cancer

Russell Rockne¹, Syed Rahmanuddin^1,2, John J. Park², and Jinha M. Park²

¹Dept. of Information Sciences/ Mathamatical Oncology, Beckman Research Institute City of Hope, Duarte, CA, United States, ²Radiology, Helford Clinical Research Hospital | Beckman Research Institute, Duarte, CA, United States

The purpose of this study is to evaluate changes in tumor volume and mean ADC before and after 90-yttrium (Y90) radioembolization for patients with metastatic liver cancer. Eighteen patients were identified in a retrospective study. Volumetric analysis of lesions before and after therapy showed a consistent increase in ADC (p<0.001), suggesting a decrease in cellularity. Changes in tumor volume measured on post-gadolinium (PG) T1 MRI were not statistically significant. Additional MRIs following Y90 treatment should be analyzed with clinical outcomes to determine whether early changes in ADC following therapy may serve as an early indicator of response.

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