Abstract #2426

Distortion-Free bSSFP-based Diffusion MRI: Preliminary Experience using an MRI-Guided Radiotherapy System

Yu Gao^1,2, Yingli Yang³, Novena Rangwala¹, and Peng Hu^1,2

¹Radiological Sciences, University of California, Los Angeles, Los Angeles, CA, United States, ²Physics and Biology in Medicine, University of California, Los Angeles, Los Angeles, CA, United States, ³Radiation Oncology, University of California, Los Angeles, Los Angeles, CA, United States

DWI is a promising imaging biomarker for tumor response evaluation, and the purpose of this work is to develop a distortion-free DW sequence that is reliable for adaptive treatment planning. ADC accuracy of our proposed diffusion-prepared segmented bSSFP-based sequence against the standard spin-echo single-shot echo-planar-imaging was quantitatively validated on a diffusion phantom. Geometric reliability was confirmed on both phantom and in-vivo experiments. Preliminary patient study on a MRI-Guided radiotherapy system showed high geometric accuracy and promising tumor detection capability. All these demonstrate the feasibility of using the DW-SSFP sequence for longitudinal tumor response evaluation and treatment planning.

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