Abstract #2429

Heterogeneity of IDH+ glioma metabolism evaluated by CSI

Benjamin C Rowland¹, Min Zhou¹, Huijun Liao¹, Nils Arvold², Raymond Y Huang³, and Alexander P Lin¹

¹Centre for Clinical Spectroscopy, Brigham and Women's Hospital, Boston, MA, United States, ²Radiation Oncology, Brigham and Women's Hospital, Boston, MA, United States, ³Radiology, Brigham and Women's Hospital, Boston, MA, United States

MR spectroscopy is a powerful technique for understanding tumour metabolism. Chemical shift imaging allows spatial variations in spectra to be observed at the cost of signal to noise and acquisition time. In this abstract we examine the heterogeneity of metabolite concentrations in both tumour and healthy tissue, in particular the onco-metabolite 2-hydroxyglutarate, to ascertain if the benefits of CSI outweigh the penalties.

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