Ben Babourina-Brooks1, Sarah Kohe1, Andrew Peet1, and Nigel Davies2
The rate of improvement in survival, among children with
brain tumours, has decreased in recent years and novel prognostic markers that
may contribute to treatment stratification and improved outcomes are required. Medulloblastoma tumours have a high rate of mortality due to their aggressive nature, however some do not. MRS can measure absolute
water proton resonance frequency (PRF), which is sensitive to temperature and
other features of the tumour microenvironment. This could be utilized as a potential prognosis marker, however has not been explored. This
study assessed the water PRF as a predictor of survival in a medulloblastoma
patients, using MRS at diagnosis.