Abstract #2430

Prediction of Medulloblastoma survival using the Water Proton Resonance Frequency

Ben Babourina-Brooks¹, Sarah Kohe¹, Andrew Peet¹, and Nigel Davies²

¹University of Birmingham, Birmingham, United Kingdom, ²University Hospitals Birmingham, Birmingham, United Kingdom

The rate of improvement in survival, among children with brain tumours, has decreased in recent years and novel prognostic markers that may contribute to treatment stratification and improved outcomes are required. Medulloblastoma tumours have a high rate of mortality due to their aggressive nature, however some do not. MRS can measure absolute water proton resonance frequency (PRF), which is sensitive to temperature and other features of the tumour microenvironment. This could be utilized as a potential prognosis marker, however has not been explored. This study assessed the water PRF as a predictor of survival in a medulloblastoma patients, using MRS at diagnosis.

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