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Abstract #2431

In-vitro 1H-MRS of living human melanoma cells at 9.4T

Katarzyna Pierzchala1, Nicolas Kunz1, and Rolf Gruetter1

1CIBM, EPFL, Lausanne, Switzerland

There is increasing need of a more human cell model to recapitulate the in-vivo cell-cell interactions, presenting physiological relevance. Magnetic resonance spectroscopy (MRS) has the potential to diagnose many tumors and to characterize their metastatic potential. In this study we present the metabolic profile of highly metastatic human melanoma cells line WM793.We demonstrate the feasibility of characterizing in-vitro living melanoma cells by 1H-MRS with a total number of 9 metabolites quantified, covering energy markers (Glc, Lac, Ace), amino acids (Glu, Ala) and anti-oxidant (Tau, Asc) and cell membrane precursor (Cho).

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