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Abstract #2433

Apparent diffusion coefficient ratio as a potential inter-institutional marker for histological grade of bladder cancer

Soichiro Yoshida1, Fumitaka Koga2, Hiroshi Tanaka3, Hiroshi Fukushima2, Yasukazu Nakanishi2, Minato Yokoyama1, Junichiro Ishioka1, Kazutaka Saito1, Yasuhisa Fujii1, and Kazunori Kihara1

1Urology, Tokyo Medical and Dental University Graduate School, Tokyo, Japan, 2Urology, Tokyo Metropolitan Cancer and Infectious diseases Center Komagome Hospital, Tokyo, Japan, 3Radiology, Ochanomizu Surugadai Clinic, Tokyo, Japan

We evaluated standardized apparent diffusion coefficient value (ADC ratio) by taking the ratio of the ADC of the cancer tissue (T-ADC) to that of the gluteus maximus (G-ADC) can be a biomarker for predicting histological grade under two different imaging conditions. Two independent bladder cancer cohorts including 107 and 47 patients were evaluated. There was a significant difference in T-ADC between the cohorts, but no significant difference in the ADC ratio was observed. The ADC ratio significantly correlated with grade, as was the T-ADC. The ADC ratio might serve as an inter-institutional biomarker for predicting histological grade of bladder cancer.

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