Abstract #2433

Apparent diffusion coefficient ratio as a potential inter-institutional marker for histological grade of bladder cancer

Soichiro Yoshida¹, Fumitaka Koga², Hiroshi Tanaka³, Hiroshi Fukushima², Yasukazu Nakanishi², Minato Yokoyama¹, Junichiro Ishioka¹, Kazutaka Saito¹, Yasuhisa Fujii¹, and Kazunori Kihara¹

¹Urology, Tokyo Medical and Dental University Graduate School, Tokyo, Japan, ²Urology, Tokyo Metropolitan Cancer and Infectious diseases Center Komagome Hospital, Tokyo, Japan, ³Radiology, Ochanomizu Surugadai Clinic, Tokyo, Japan

We evaluated standardized apparent diffusion coefficient value (ADC ratio) by taking the ratio of the ADC of the cancer tissue (T-ADC) to that of the gluteus maximus (G-ADC) can be a biomarker for predicting histological grade under two different imaging conditions. Two independent bladder cancer cohorts including 107 and 47 patients were evaluated. There was a significant difference in T-ADC between the cohorts, but no significant difference in the ADC ratio was observed. The ADC ratio significantly correlated with grade, as was the T-ADC. The ADC ratio might serve as an inter-institutional biomarker for predicting histological grade of bladder cancer.

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