Abstract #2434

GluCEST MRI: A Biomarker for Glutamine Metabolism in Cancer

Rong Zhou¹, Puneet Bagga¹, Kavindra Nath¹, David Mankoff¹, Hari Hariharan¹, and Ravinder Reddy¹

¹Radiology, University of Pennsylvania, Philadelphia, PA, United States

We presented the very first evaluation of glutamate chemical exchange saturation transfer (GluCEST) MRI to detect pharmacodynamic effect of small molecule drugs that target cancer glutaminolysis pathway. Conversion of glutamine to glutamate is a rate limiting step along this pathway. Inhibition of this conversion leads to reduction of cellular glutamate concentration that can be detected by GluCEST in vivo and confirmed by ex vivo high resolution 1H MRS of tumor homogenates.

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