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Abstract #2434

GluCEST MRI: A Biomarker for Glutamine Metabolism in Cancer

Rong Zhou1, Puneet Bagga1, Kavindra Nath1, David Mankoff1, Hari Hariharan1, and Ravinder Reddy1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States

We presented the very first evaluation of glutamate chemical exchange saturation transfer (GluCEST) MRI to detect pharmacodynamic effect of small molecule drugs that target cancer glutaminolysis pathway. Conversion of glutamine to glutamate is a rate limiting step along this pathway. Inhibition of this conversion leads to reduction of cellular glutamate concentration that can be detected by GluCEST in vivo and confirmed by ex vivo high resolution 1H MRS of tumor homogenates.

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