Abstract #2435

Use of iron contrast agents to detect brain tumor treatment response based on stimulating the innate immune system

Yang Runze^1,2, Susobhan Sarkar², Daniel J Korchinski¹, Ying Wu¹, V Wee Yong^2,3, and Jeff F. Dunn^1,2

¹Radiology, University of Calgary, Calgary, AB, Canada, ²Clinical Neuroscience, University of Calgary, Calgary, AB, Canada, ³Oncology, University of Calgary, Calgary, AB, Canada

Glioblastoma Multiforme (GBM) is the most aggressive brain cancer with an abysmal prognosis. It has been shown that monocytes can be activated to suppress GBM stem cells using Amphotericin B (Amp B). We propose that monocytes can be labeled using intravenous injection of ultra-small iron oxide nanoparticles (USPIO), which will allow us to detect a rapid treatment response. We showed that Amp B treated animals significantly decreased T2* compared to vehicles, showing the presence of USPIO within the tumor. This shows that USPIO can be an effective tool to monitor cancer therapies that stimulate innate immunity.

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