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Abstract #2436

Diffusion weighted magnetic resonance imaging as an early predictor of survival in patients with liver-dominant metastatic colorectal cancer following 90-Yttrium-microsphere radioembolization

Frederic Carsten Schmeel1, Birgit Simon1, Julian Alexander Luetkens1, Frank Träber1, Leonard Christopher Schmeel1, Hans Heinz Schild1, and Dariusch Reza Hadizadeh1

1Department of Radiology, University Hospital Bonn, Bonn, Germany

Imaging-based response assessment to local interventional therapies is essential for further therapy decisions in patients with advanced malignancies. Therefore, we investigated whether early post-therapeutic changes in diffusion-weighted MRI using quantifications of the apparent diffusion coefficient (ADC) could predict the outcome of patients with liver-dominant metastatic colorectal cancer after radioembolization with 90-Yttrium microspheres (RE). Uni- and multivariate survival analyses were performed comparing various variables with potential impact on overall survival. Our results reveal that an increase in the post-therapeutic minimal ADC remained the strongest and only independent predictor of overall survival shortly after radioembolization.

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