Multiparameter MRI Response Assessment in a Phase I Trial of Hypofractionated Stereotactic Irradiation with Pembrolizumab and Bevacizumab in Patients with Recurrent High Grade Gliomas
Olya Stringfield1, John Arrington2, Solmaz Sahebjam3, and Natarajan Raghunand1
1Cancer Imaging & Metabolism, Moffitt Cancer Center, Tampa, FL, United States, 2Radiology, Moffitt Cancer Center, Tampa, FL, United States, 3Neuro-Oncology, Moffitt Cancer Center, Tampa, FL, United States
In this ongoing phase 1 study, we are investigating combined pembrolizumab and bevacizumab therapy with hypofractionated
radiotherapy in recurrent glioma. The objective of this work is to develop a non-invasive
response assessment measure using multiparameter MRI (mpMRI) scans acquired as part of clinical care which may
precede volumetric changes in response to therapy.
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