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Abstract #2443

Can Diffusion Weighted MRI Assess Early Response of Lymphadenopathy to Induction Chemotherapy in Nasopharyngeal Cancer: A Heterogeneity Analysis Approach

Manijeh Beigi1, Anahita Fathi Kazerooni1, Mojtaba Safari1, Marzieh Alamolhoda2, Ahmad Ameri3, Shiva Moghdam4, Mohsen Shojaee Moghdam5, and Hamidreza Saligheh Rad1

1Medical Physics and Biomedical Engineering, School of Medicine, Quantitative MR Imaging and Spectroscopy Group, Research Center for Cellular and Molecular Imaging, Institute for Advanced Medical Imaging, Tehran, Iran, 2Statistics, Shiraz University of Medical Science, Shiraz, Iran, 3Oncology, Shahid Beheshti University of Medical Science, Tehran, Iran, 4Oncology, Tehran, Iran, 5Payambaran Imaging Center, Tehran, Iran

Induction chemotherapy is an effective way to control subclinical metastasis in locally-advanced nasopharyngeal cancer patients. Diffusion-weighted MRI is a noninvasive imaging technique allowing some degree of tissue characterization by showing and quantifying molecular diffusion. Histogram analysis on ADC map could be carried out to reveal physiological alterations early after IC. For this purpose, several quantitative metrics from ADC-map were explored to obtain the most accurate feature(s) as potential predictive biomarker for early response of the lymphnode to IC. If the outcome can be predicted at an early stage of the treatment, the patient could be spared from unnecessary treatment toxicity.

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