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Abstract #2442

MRI biomarkers for pancreatic ductal adenocarcinoma

Navid Farr1, Paolo Provenzano2, Joshua Park3, Sunil Hingorani2, and Donghoon Lee3

1Department of Bioengineering, University of Washington, Seattle, WA, United States, 2Fred Hutchinson Cancer Research Center, Seattle, WA, United States, 3Department of Radiology, University of Washington, Seattle, WA, United States

Pancreatic cancer is a devastating disease with poor prognosis. Pancreatic tumor therapy has been ineffective in part because pancreatic tumors have a dense stroma inhibiting penetration of chemotherapeutic drugs into the tumor. We performed multi-parametric MRI at high resolution to noninvasively assess tumor progression and responses to effective treatment. We used T1 and T2 relaxation, diffusion, magnetization transfer effects along with 3 dimensional volume measurements to characterize the tumors. MR measurements were then compared with histopathological results.

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