Abstract #2446

Prostate Cancer: DCE-MRI parameter changes during radiotherapy

Lucy Elizabeth Kershaw^1,2, Andrew McPartlin^2,3, Ben Taylor⁴, Ananya Choudhury^2,3, and Marcel van Herk²

¹CMPE, The Christie NHSFT, Manchester, United Kingdom, ²Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, United Kingdom, ³Oncology, The Christie NHSFT, Manchester, United Kingdom, ⁴Radiology, The Christie NHSFT, Manchester, United Kingdom

In this pilot work, our aim was to measure plasma flow (F_p) and permeability-surface area product (PS) through the course of RT in prostate tumour and normal tissue to determine whether significant changes could be detected early in treatment. We detected significant increases in F_p and PS during radiotherapy in this small patient group.

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