Abstract #2447

The feasibility of performing intravoxel incoherent motion MRI for esophageal cancer and an initial comparison with dynamic contrast-enhanced MRI

Sophie E. Heethuis¹, Lucas Goense^1,2, Peter S.N. van Rossum^1,2, Irene M. Lips¹, Richard van Hillegersberg², Jelle P. Ruurda², Marco van Vulpen¹, Gert J. Meijer¹, Jan J.W. Lagendijk¹, and Astrid L.H.M.W. van Lier¹

¹Department of Radiotherapy, UMC Utrecht, Utrecht, Netherlands, ²Department of Surgery, UMC Utrecht, Utrecht, Netherlands

The aim of this study was to investigate whether intravoxel incoherent motion (IVIM) MRI could be a non-invasive alternative for dynamic contrast-enhanced (DCE) MRI for response prediction in patients with esophageal cancer. The feasibility of IVIM was researched, followed by a first comparison with DCE-MRI. It was found that non-rigid registration improved the fitting of the IVIM parameters significantly. Comparison of IVIM and DCE-MRI suggested an inverse relation between perfusion fraction and area-under-the-concentration curve (AUC).

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