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Abstract #2447

The feasibility of performing intravoxel incoherent motion MRI for esophageal cancer and an initial comparison with dynamic contrast-enhanced MRI

Sophie E. Heethuis1, Lucas Goense1,2, Peter S.N. van Rossum1,2, Irene M. Lips1, Richard van Hillegersberg2, Jelle P. Ruurda2, Marco van Vulpen1, Gert J. Meijer1, Jan J.W. Lagendijk1, and Astrid L.H.M.W. van Lier1

1Department of Radiotherapy, UMC Utrecht, Utrecht, Netherlands, 2Department of Surgery, UMC Utrecht, Utrecht, Netherlands

The aim of this study was to investigate whether intravoxel incoherent motion (IVIM) MRI could be a non-invasive alternative for dynamic contrast-enhanced (DCE) MRI for response prediction in patients with esophageal cancer. The feasibility of IVIM was researched, followed by a first comparison with DCE-MRI. It was found that non-rigid registration improved the fitting of the IVIM parameters significantly. Comparison of IVIM and DCE-MRI suggested an inverse relation between perfusion fraction and area-under-the-concentration curve (AUC).

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