Abstract #2448

Restriction Spectrum Imaging based tumor cellularity performs better than ADC in patients newly diagnosed with Glioblastoma Multiforme

AnithaPriya Krishnan¹, Carrie R. McDonald¹, Nikdokht Farid², Anders M. Dale^1,3, and Nathan S. White^1,3

¹MMIL, Radiology, University of San Diego, La Jolla, CA, United States, ²Division of Neuroradiology, University of San Diego, La Jolla, CA, United States, ³Center for Translational Imaging and Precision Medicine, University of San Diego, La Jolla, CA, United States

Contrast enhancing (CE) volumes are unreliable in the pseudo-progression window post radiotherapy and ADC based estimate of tumor cellularity is significantly affected by edema. Here, we provide preliminary evidence that Restriction Spectrum Imaging (RSI) based tumor cellularity performs better than ADC, supplements structural volumes and is significantly predictive of overall survival (OS). The study also highlights the need for higher b values as the association of ADC (in CE) with outcomes was observed only when high b values were used for ADC estimation and with b=1500s/mm2, ADC in edema ROI was not independent of edema volume (r=0.7)

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