Abstract #2451

Quantitative Evaluation of the Effect of Bone on Pelvic Lesion Uptake for MR-based Attenuation Correction on an Integrated Time-of-Flight PET/MRI System

Andrew Leynes¹, Jaewon Yang¹, Dattesh Shanbhag², Sandeep Kaushik², Florian Wiesinger³, Youngho Seo¹, Thomas Hope¹, and Peder Larson¹

¹University of California San Francisco, San Francisco, CA, United States, ²GE Global Research, Bangalore, India, ³GE Global Research, Munich, Germany

The current clinical standard for extracranial MR-based attenuation correction (MRAC) on hybrid PET/MRI systems is the use of a Dixon-type sequence to generate a continuous-value fat-water map. The exclusion of bone in Dixon MRAC contributes a clinically significant amount of underestimation in bone lesion uptake. Bone information from a zero echo-time (ZTE) MRI pulse sequence is combined with the Dixon MRAC to produce a hybrid ZTE-Dixon MRAC. The work demonstrates, using PET/MR patient data, that the Dixon MRAC (neglecting bone) is underestimating bone lesion uptake by a clinically significant amount (>10%) when compared to the hybrid MRAC (including bone).

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