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Abstract #2455

Assessing Myeloma Focal Lesion Conspicuity on Dixon Images

Timothy James Pengilley Bray1, Saurabh Singh1, Arash Latifoltojar1, Kannan Rajesparan1, Farzana Rahman1, Alan Bainbridge2, Shonit Punwani1, and Margaret A Hall-Craggs1

1Centre for Medical Imaging, University College London, London, United Kingdom, 2Medical Physics, University College London, London, United Kingdom

Dixon imaging is becoming more widely used in multiple myeloma (MM) and can provide both functional and anatomical information. We observed that myeloma lesions seemed more conspicuous on fat only (FO) images than on conventional in-phase T1, and therefore hypothesised that lesion detection rates would be higher on FO images. In this research, we show that reader sensitivity, positive predictive value and confidence are indeed higher on FO images. This may be because myeloma lesions cause a proportionately greater change in fat content than in water content. We suggest that Dixon imaging should be used in preference to T1 imaging alone when performing WB-MRI.

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