Abstract #2455

Assessing Myeloma Focal Lesion Conspicuity on Dixon Images

Timothy James Pengilley Bray¹, Saurabh Singh¹, Arash Latifoltojar¹, Kannan Rajesparan¹, Farzana Rahman¹, Alan Bainbridge², Shonit Punwani¹, and Margaret A Hall-Craggs¹

¹Centre for Medical Imaging, University College London, London, United Kingdom, ²Medical Physics, University College London, London, United Kingdom

Dixon imaging is becoming more widely used in multiple myeloma (MM) and can provide both functional and anatomical information. We observed that myeloma lesions seemed more conspicuous on fat only (FO) images than on conventional in-phase T1, and therefore hypothesised that lesion detection rates would be higher on FO images. In this research, we show that reader sensitivity, positive predictive value and confidence are indeed higher on FO images. This may be because myeloma lesions cause a proportionately greater change in fat content than in water content. We suggest that Dixon imaging should be used in preference to T1 imaging alone when performing WB-MRI.

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