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Abstract #2456

Proton Magnetic Resonance Spectroscopy (1-H MRS) of Sputum and Exhaled Breath Condensate: A Non-invasive Tool for Lung Cancer Screening

Naseer Ahmed1, Tedros Bezabeh2,3, Renelle Myers 4, Omkar B Ijare3, Shantanu Banerji 1, Reem Alomran 1, Zoann Nugent 1, and Zoheir Bshouty 4

1CancerCare Manitoba, Winnipeg, MB, Canada, 2Chemistry, University of Guam, Mangilao, Guam, 3Chemistry, University of Winnipeg, Winnipeg, MB, Canada, 4Health Sciences Centre, Winnipeg, MB, Canada

We undertook this study to determine if 1H Magnetic Resonance Spectroscopy (MRS) can provide an alternate tool for the screening of lung cancer. Metabolic profiles of sputum and exhaled breath condensate (EBC) samples were obtained from 15 patients (cancer, n=8 and control, n=7) using a Bruker Avance 400 MHz NMR spectrometer. Methanol was detected at a significantly lower concentration in the EBC samples (p<0.05). Absence of glucose and lower concentration of glycoprotein (p<0.05) were observed in the sputum samples of the cancer patients. MRS may serve as a screening tool for lung cancer in high-risk patients but this requires validation in a larger study.

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