Abstract #2456

Proton Magnetic Resonance Spectroscopy (1-H MRS) of Sputum and Exhaled Breath Condensate: A Non-invasive Tool for Lung Cancer Screening

Naseer Ahmed¹, Tedros Bezabeh^2,3, Renelle Myers ⁴, Omkar B Ijare³, Shantanu Banerji ¹, Reem Alomran ¹, Zoann Nugent ¹, and Zoheir Bshouty ⁴

¹CancerCare Manitoba, Winnipeg, MB, Canada, ²Chemistry, University of Guam, Mangilao, Guam, ³Chemistry, University of Winnipeg, Winnipeg, MB, Canada, ⁴Health Sciences Centre, Winnipeg, MB, Canada

We undertook this study to determine if ¹H Magnetic Resonance Spectroscopy (MRS) can provide an alternate tool for the screening of lung cancer. Metabolic profiles of sputum and exhaled breath condensate (EBC) samples were obtained from 15 patients (cancer, n=8 and control, n=7) using a Bruker Avance 400 MHz NMR spectrometer. Methanol was detected at a significantly lower concentration in the EBC samples (p<0.05). Absence of glucose and lower concentration of glycoprotein (p<0.05) were observed in the sputum samples of the cancer patients. MRS may serve as a screening tool for lung cancer in high-risk patients but this requires validation in a larger study.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.