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Abstract #2460

Validation of Interstitial Volume Fraction Quantification Performed with Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Skeletal Swine Muscle

Stefan Hindel1, Anika Söhner1, Marc Maaß2, and Lutz Lüdemann1

1University Hospital Essen, Essen, Germany, 2Wesel Protestant Hospital, Wesel, Germany

We assessed the accuracy of interstitial volume fraction v(e) measurements in low-perfused tissue performed using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with a gadolinium-based contrast agent. A 3D gradient echo sequence with k-space-sharing was used to determine v(e) in muscle tissue of twelve pigs. The evaluation was performed with the simple and extended Tofts model and the 2-compartment exchange model using different acquisition durations (ADs). The v(e) values determined by MRI were compared with the histologic analysis of muscle tissue sections. There was good agreement between histology and DCE-MRI modeling but also a strong dependence on AD with the Tofts models.

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