Stefan Hindel1, Anika Söhner1, Marc Maaß2, and Lutz Lüdemann1
We estimated the
blood volume fraction in low perfused tissue using dynamic contrast-enhanced
magnetic resonance imaging (DCE-MRI). The blood volume fraction v(b) was
measured in hind leg muscle of pigs weighing approx. 60 kg. MRI was performed
using a 3D gradient echo sequence with k-space-sharing and either a
gadolinium-based (gadoterate meglumine) or an intravascular contrast agent
(gadofosveset trisodium). Comparison of the different DCE-MRI methods with
histology revealed good agreement between histological findings and the results
obtained with the 2-compartment exchange model, bolus deconvolution and
equilibrium MRI.
