Abstract #2461

Quantification of Blood Volume Fraction Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Skeletal Swine Muscle

Stefan Hindel¹, Anika Söhner¹, Marc Maaß², and Lutz Lüdemann¹

¹University Hospital Essen, Essen, Germany, ²Wesel Protestant Hospital, Wesel, Germany

We estimated the blood volume fraction in low perfused tissue using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). The blood volume fraction v(b) was measured in hind leg muscle of pigs weighing approx. 60 kg. MRI was performed using a 3D gradient echo sequence with k-space-sharing and either a gadolinium-based (gadoterate meglumine) or an intravascular contrast agent (gadofosveset trisodium). Comparison of the different DCE-MRI methods with histology revealed good agreement between histological findings and the results obtained with the 2-compartment exchange model, bolus deconvolution and equilibrium MRI.

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