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Abstract #2461

Quantification of Blood Volume Fraction Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Skeletal Swine Muscle

Stefan Hindel1, Anika Söhner1, Marc Maaß2, and Lutz Lüdemann1

1University Hospital Essen, Essen, Germany, 2Wesel Protestant Hospital, Wesel, Germany

We estimated the blood volume fraction in low perfused tissue using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). The blood volume fraction v(b) was measured in hind leg muscle of pigs weighing approx. 60 kg. MRI was performed using a 3D gradient echo sequence with k-space-sharing and either a gadolinium-based (gadoterate meglumine) or an intravascular contrast agent (gadofosveset trisodium). Comparison of the different DCE-MRI methods with histology revealed good agreement between histological findings and the results obtained with the 2-compartment exchange model, bolus deconvolution and equilibrium MRI.

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