Abstract #2462

A simplified spin and gradient echo (SAGE) DSC-MRI approach for the simultaneous assessment of brain tumor perfusion, permeability, and cellularity

Ashley M Stokes¹, Jack T Skinner², and C. Chad Quarles¹

¹Department of Imaging Research, Barrow Neurological Institute, Phoenix, AZ, United States, ²National Comprehensive Cancer Network, Philadelphia, PA, United States

Dynamic susceptibility contrast (DSC-MRI) MRI is routinely used for brain tumor imaging and has shown promise as an early biomarker for treatment response. Conventional DSC-MRI is susceptible to contrast agent leakage effects, reducing the reliability of the resulting blood volume maps. The use of a simplified spin and gradient echo (SAGE) sequence, combined with robust processing strategies for correction of leakage effects, could facilitate more rapid clinical translation and adoption of DSC-MRI for brain tumor imaging. Taken together, the simplified SAGE approach and subsequence leakage correction provides a clinically feasible strategy for the simultaneous assessment tumor perfusion, permeability and cellularity.

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