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Abstract #2473

Dependence of Breast Pharmacokinetic Parameters on pre-contrast T1 and flip angle

Subashini Srinivasan1, Bruce L Daniel1, and Brian A Hargreaves1

1Radiology, Stanford University, Stanford, CA, United States

Pharmacokinetic (PK) models have been used to estimate physiological parameters such as permeability and dispersion of the contrast agent and is estimated using the acquired signal, pre-contrast T10, and the acquisition flip angle. In this work, we have determined the dependence of the dispersion models’ and Tofts models’ PK parameters on T10 and B1 maps, as well as the errors introduced by using constant T10 and B1 values in 11 biopsy-proven tumors. Our results show that PK parameters such as kep of Tofts model and kappa of mLDRW dispersion model are less dependent on T10 and B1 and could potentially be used with higher accuracy and precision even when T10 and B1 maps are not acquired.

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