Abstract #2474

Estimation of breast tumour tissue diffusion parameters from histological images and Monte-Carlo simulations

David Naves Sousa¹, Filipa Borlinhas¹, and Hugo Alexandre Ferreira¹

¹Institute of Biophysics and Biomedical Engineering, Faculdade de Ciências da Universidade de Lisboa, Lisboa, Portugal

Diffusion-Weighted Imaging is a MRI technique that is able to distinguish between benign and malignant breast tumours via the Apparent Diffusion Coefficient (ADC). Nevertheless, this parameter provides very limited information regarding tissue microstructure. Here, is presented an approach to estimate the intracellular (Di) and extracellular (De) diffusion coefficients, and cell membrane permeability of tumour tissues which makes use of known ADC values, histological images and Monte-Carlo simulations of diffusion processes. Results show that distinct combinations of (Di, De, P) correlate with tumour type, and that a decreased De was observed in malignant tumours in agreement with known extracellular matrix changes.

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