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Abstract #2482

Application of Histogram Analysis of Pharmacokinetic Parameters in Dynamic Contrast-Enhanced MR Imaging of Breast lesions with CAIPIRINHA-Dixon-TWIST-VIBE Technique

Yiqi Hu1, Tao Ai1, and Liming Xia1

1Tongji Hospital, department of radiology, Wuhan, China, People's Republic of

The overlap of pharmacokinetic parameters values exists between benign and malignant lesions. Most previous studies chose mean pharmacokinetic parameters when elevating the state of breast lesions perfusion. However, tumors are heterogeneous that are marked by microenvironmental factors and thus manifests as radiologic heterogeneity. The mean pharmacokinetic parameter values may overlook the subtle but important difference between breast lesions. Thus, the aim of our study is to investigate the feasibility of histogram analysis of pharmacokinetic parameters including Ktrans, kep, ve in breast DCE-MRI imaging and determine which metric of each pharmacokinetic parameter may best help differentiate benign from malignant lesions.

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