Abstract #2491

B1+ Inhomogeneity Correction for Estimation of Pharmacokinetic Parameters through an Approximation Approach

Xinran Zhong^1,2, Novena Rangwala¹, Steven Raman¹, Daniel Margolis¹, Holden Wu^1,2, and Kyunghyun Sung^1,2

¹Radiological Sciences, University of California, Los Angeles, Los Angeles, CA, United States, ²Physics and Biology in Medicine, University of California, Los Angeles, Los Angeles, CA, United States

A simplified version of the B₁⁺ correction method using an approximation model was proposed for estimation of pharmacokinetic modeling parameters. The proposed method was evaluated in both simulation and in vivo DCE-MRI data, and was applied to DCE-MRI with 63 suspicious lesions from two MRI systems to investigate B₁⁺ induced errors in K^trans. Significant difference of estimated K^trans distributions was observed between two systems, showing it's necessary to perform B₁⁺ correction for DCE-MRI analysis between systems.

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