Abstract #2495

Molecular Imaging and Targeting of Hypoxic Microenvironment

Balaji Krishnamachary¹, Louis Dore-Savard¹, Santosh Kumar Bharti¹, Flonne Wildes¹, Yelena Mironchik¹, and Zaver M Bhujwalla¹

¹Radiology, Johns Hopkins University, Baltimore, MD, United States

Hypoxic environments frequently exist in solid tumors and result in resistance to therapy and the evolution of a more lethal phenotype. Here, we have genetically engineered human prostate cancer PC-3 cells to report on hypoxia and also express yeast cytosine deaminase under the control of hypoxia response elements to convert the prodrug 5-fluorocytosine to 5-Fluorouracil. We also show that selective killing of hypoxic cells significantly reduces tumor growth.

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