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Abstract #2496

Texture analysis of equivocal Likert scored 3/5 peripheral zone prostate lesions on mpMRI

Aishah Azam1, Dario Picone2, Mrishta Brizmohun Appayya2, Balaji Ganeshan3, Nikolaos Dikaios2, Raymond Endozo3, Ashley Groves3, Hashim Ahmed4, and Shonit Punwani1

1University College London Hospital, London, United Kingdom, 2Centre for Medical Imaging, University College London, London, United Kingdom, 3Institute of Nuclear Medicine, University College London, London, United Kingdom, 4Division of Surgery, University College London Hospital, London, United Kingdom

Approximately 30% of multiparametricMRIs for peripheral zone prostate cancer are scored as “equivocal”. Texture analysis was performed on 66 patients with “equivocal” mpMRIs using TexRad software to see if there were any particular textural differences between patients with significant cancer and non-significant disease on biopsy. We found average entropy on ADC sequences of the PZ is reduced in patients with significant cancer (p=0.003). Using an entropy threshold of <5.99 demonstrates a sensitivity of 0.88 and specificity is 0.60 for detecting significant PZ prostate cancer. Therefore, ADC entropy can help assess “equivocal” studies and enable selection of patients for biopsy and treatment.

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