Abstract #2496

Texture analysis of equivocal Likert scored 3/5 peripheral zone prostate lesions on mpMRI

Aishah Azam¹, Dario Picone², Mrishta Brizmohun Appayya², Balaji Ganeshan³, Nikolaos Dikaios², Raymond Endozo³, Ashley Groves³, Hashim Ahmed⁴, and Shonit Punwani¹

¹University College London Hospital, London, United Kingdom, ²Centre for Medical Imaging, University College London, London, United Kingdom, ³Institute of Nuclear Medicine, University College London, London, United Kingdom, ⁴Division of Surgery, University College London Hospital, London, United Kingdom

Approximately 30% of multiparametricMRIs for peripheral zone prostate cancer are scored as “equivocal”. Texture analysis was performed on 66 patients with “equivocal” mpMRIs using TexRad software to see if there were any particular textural differences between patients with significant cancer and non-significant disease on biopsy. We found average entropy on ADC sequences of the PZ is reduced in patients with significant cancer (p=0.003). Using an entropy threshold of <5.99 demonstrates a sensitivity of 0.88 and specificity is 0.60 for detecting significant PZ prostate cancer. Therefore, ADC entropy can help assess “equivocal” studies and enable selection of patients for biopsy and treatment.

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