Abstract #2499

Utility of computed diffusion-weighted imaging for predicting aggressiveness of prostate cancer

Yuma Waseda¹, Soichiro Yoshida¹, Taro Takahara², Hiroshi Tanaka³, Minato Yokoyama¹, Junichiro Ishioka¹, Yoh Matsuoka¹, Noboru Numao¹, Kazutaka Saito¹, Yasuhisa Fujii¹, and Kazunori Kihara¹

¹Urology, Tokyo Medical and Dental University Graduate School, Tokyo, Japan, ²Biomedical Engineering, Tokai University School of Engineering, Kanagawa, Japan, ³Radiology, Ochanomizu Surugadai Clinic, Tokyo, Japan

Apparent diffusion coefficient (ADC) value is reported to reflect aggressiveness of prostate cancer (PCa). Yet ADC value depends on imaging protocols. To overcome the limitation, we developed a simple method to discriminate aggressive PCa using computed DWI (cDWI). We analyzed changes in cDWI signal of 51 PCa, that results from increasing b-value. At b = 700 sec/mm², signal intensity in Gleason grade 4-5 was higher than that in normal, whereas in Gleason grade 3 cancer it was equal to or lower than that in normal (sensitivity/specificity: 97.0%/72.2%). Semi-quantitative analysis using DWI might be a simple method for discriminating aggressive PCa.

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