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Abstract #2499

Utility of computed diffusion-weighted imaging for predicting aggressiveness of prostate cancer

Yuma Waseda1, Soichiro Yoshida1, Taro Takahara2, Hiroshi Tanaka3, Minato Yokoyama1, Junichiro Ishioka1, Yoh Matsuoka1, Noboru Numao1, Kazutaka Saito1, Yasuhisa Fujii1, and Kazunori Kihara1

1Urology, Tokyo Medical and Dental University Graduate School, Tokyo, Japan, 2Biomedical Engineering, Tokai University School of Engineering, Kanagawa, Japan, 3Radiology, Ochanomizu Surugadai Clinic, Tokyo, Japan

Apparent diffusion coefficient (ADC) value is reported to reflect aggressiveness of prostate cancer (PCa). Yet ADC value depends on imaging protocols. To overcome the limitation, we developed a simple method to discriminate aggressive PCa using computed DWI (cDWI). We analyzed changes in cDWI signal of 51 PCa, that results from increasing b-value. At b = 700 sec/mm2, signal intensity in Gleason grade 4-5 was higher than that in normal, whereas in Gleason grade 3 cancer it was equal to or lower than that in normal (sensitivity/specificity: 97.0%/72.2%). Semi-quantitative analysis using DWI might be a simple method for discriminating aggressive PCa.

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