Abstract #2500

Assessment of Kurtosis Model for Diffusion-Weighted Imaging and T1 Relaxation Time in the Rotating Frame of Prostate Cancer

Huiyan Li¹, Yingjie Mei², Queenie Chan³, and Yikai Xu¹

¹Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, China, People's Republic of, ²Philips Healthcare, Guangzhou, China, People's Republic of, ³Philips Healthcare, HongKong, China, People's Republic of

Kurtosis model based on Gaussian distribution may be an appropriate condition in prostate. T1rho can detect slow molecular motions of tissue water or proton chemical exchange selectively, which may alter in prostate cancer (PCa). Parameters Dapp, Kapp and T1 relaxation time obtained from T1rho sequence and kurtosis model for DWI underwent statistic analysis between PCa and benign prostate hyperplasia（BPH）patients. Our study showed that Kapp and Dapp could be an effective parameter on PCa detection, while T1rho failed to differentiate PCa and BPH.

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