Abstract #2507

In vivo Enzyme Activity Measurements with Hyperpolarized C13 Pyruvate in a Transgenic Tumor Mouse Model

Zihan Zhu^1,2, Peder E.Z. Larson¹, Hsin-Yu Chen^1,2, Peter J Shin¹, Robert A Bok¹, John Kurhanewicz¹, and Daniel B Vigneron¹

¹Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ²UC Berkeley-UCSF Graduate Program in Bioengineering, UC Berkeley and UCSF, San Francisco, CA, United States

Hyperpolarized ¹³C MRI has been an emerging tool for in vivo enzymatic activity assessment. In this study, two dynamic hyperpolarized ¹³C sequences were compared in the same animal for two sequential injections in a transgenic prostate tumor murine model. The results suggested that the dynamic fitted metabolic conversion rates acquired from the two approaches were highly correlated.

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