Abstract #2507

In vivo Enzyme Activity Measurements with Hyperpolarized C13 Pyruvate in a Transgenic Tumor Mouse Model

Zihan Zhu^1,2, Peder E.Z. Larson¹, Hsin-Yu Chen^1,2, Peter J Shin¹, Robert A Bok¹, John Kurhanewicz¹, and Daniel B Vigneron¹

¹Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ²UC Berkeley-UCSF Graduate Program in Bioengineering, UC Berkeley and UCSF, San Francisco, CA, United States

Hyperpolarized ¹³C MRI has been an emerging tool for in vivo enzymatic activity assessment. In this study, two dynamic hyperpolarized ¹³C sequences were compared in the same animal for two sequential injections in a transgenic prostate tumor murine model. The results suggested that the dynamic fitted metabolic conversion rates acquired from the two approaches were highly correlated.

This abstract and the presentation materials are available to members only; a login is required.

Join Here