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Abstract #2507

In vivo Enzyme Activity Measurements with Hyperpolarized C13 Pyruvate in a Transgenic Tumor Mouse Model

Zihan Zhu1,2, Peder E.Z. Larson1, Hsin-Yu Chen1,2, Peter J Shin1, Robert A Bok1, John Kurhanewicz1, and Daniel B Vigneron1

1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2UC Berkeley-UCSF Graduate Program in Bioengineering, UC Berkeley and UCSF, San Francisco, CA, United States

Hyperpolarized 13C MRI has been an emerging tool for in vivo enzymatic activity assessment. In this study, two dynamic hyperpolarized 13C sequences were compared in the same animal for two sequential injections in a transgenic prostate tumor murine model. The results suggested that the dynamic fitted metabolic conversion rates acquired from the two approaches were highly correlated.

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