Meeting Banner
Abstract #2508

Investigating Prostate Cancer Aggressiveness with Hyperpolarized 13C-Urea + 13C-Pyruvate Perfusion & Metabolic Imaging of Transgenic Primary and Metastatic Tumors

Hsin-Yu Chen1, Peder E.Z. Larson1,2, Robert A. Bok2, Cornelius von Morze2, Renuka Sriram2, Romelyn Delos Santos2, Justin Delos Santos2, Jeremy W. Gordon2, John Kurhanewicz1,2, and Daniel B. Vigneron1,2

1Graduate Program in Bioengineering, UCSF and UC Berkeley, University of California, San Francisco, San Francisco, CA, United States, 2Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States

An unmet clinical need facing the management of prostate cancer is an accurate method for distinguishing aggressive prostate cancer from indolent disease. The project investigated the use of hyperpolarized (HP) 13C 3D CS-EPSI imaging of co-polarized 13C-urea + 13C-pyruvate to provide this distinction by simultaneously measuring metabolism and perfusion. Significantly higher pyruvate-to-lactate conversion rates, kPL, (P<0.00001) and significantly (P<0.004) lower urea perfusion were detected in high-grade tumors compared to low-grade tumor. Lymph-node metastases demonstrated high metabolic conversion (P>0.8) and urea perfusion not significantly (P>0.4) different than high-grade primary tumor.

This abstract and the presentation materials are available to members only; a login is required.

Join Here