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Abstract #2509

The effects of noise on pharmacokinetic analysis of the apparent conversion of hyperpolarized pyruvate

Changyu SUN1, Christopher M. Walker1, and James A. Bankson1

1Department of Imaging Physics,The University of Texas MD Anderson Cancer Center, Houton, TX, United States

Effects of noise and bias in signal and different parameters in the kinetic model affects the reproducibility of the estimation of the apparent rate of conversion of hyperpolarized (HP) pyruvate into HP lactate (kpl). The purpose of this study is to investigate the effect of signal to noise ratio for a pharmacokinetic model with two chemical and two physical compartments in estimating kpl. We examine the kpl estimated using the kinetic model by the simulated HP data with a variety of SNRs (10~50) by 95% confidence interval, mean and standard deviation. The results demonstrate that SNR affects the reproducibility of the estimation of kpl by kinetic analysis and the reproducibility of kpl estimated decreases quickly below an SNR threshold of ~25.

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