Abstract #2509

The effects of noise on pharmacokinetic analysis of the apparent conversion of hyperpolarized pyruvate

Changyu SUN¹, Christopher M. Walker¹, and James A. Bankson¹

¹Department of Imaging Physics,The University of Texas MD Anderson Cancer Center, Houton, TX, United States

Effects of noise and bias in signal and different parameters in the kinetic model affects the reproducibility of the estimation of the apparent rate of conversion of hyperpolarized (HP) pyruvate into HP lactate (kpl). The purpose of this study is to investigate the effect of signal to noise ratio for a pharmacokinetic model with two chemical and two physical compartments in estimating kpl. We examine the kpl estimated using the kinetic model by the simulated HP data with a variety of SNRs (10~50) by 95% confidence interval, mean and standard deviation. The results demonstrate that SNR affects the reproducibility of the estimation of kpl by kinetic analysis and the reproducibility of kpl estimated decreases quickly below an SNR threshold of ~25.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.