Abstract #2510

Assessment of cHSA-PEO (2000)16-Gd in breast cancer xenografts on chicken chorioallantoic membrane @ 11.7T

Zhi Zuo^1,2,3, Tatiana Syrovets⁴, Tao Wang⁵, Yu-zhou Wu⁵, Felicitas Genze⁴, Alireza Abaei³, Ina Vernikouskaya², Wei-na Liu⁵, Gen-shan Ma¹, Tanja Weil⁵, Thomas Simmet⁴, and Volker Rasche^2,3

¹Department of Cardiology, Zhongda Hospital, Medical School of Southeast University, Nanjing, China, People's Republic of, ²Department of Internal Medicine II, University Hospital Ulm, Ulm, Germany, ³Core Facility Small Animal MRI, Medical Faculty, Ulm University, Ulm, Germany, ⁴Institute of Pharmacology of Natural Products and Clinical Pharmacology, Ulm University, Ulm, Germany, ⁵Institute of Organic Chemistry III, Ulm University, Ulm, Germany

High-resolution MRI and chicken chorioallantoic membrane (CAM) cancer xenografts model are employed for the assessment of bio-distribution of polypeptide hybrid biomaterials cHSA-PEO (2000)₁₆-Gd. The breast carcinomas were planted on the CAM, which were intravascular injected with cHSA-PEO (2000)₁₆-Gd, gadofosveset (Vasovist®) and gadobenate dimeglumine (Multihance®) before MR scanning. The detailed internal structures of tiny cancer were clearly highlighted, which was proven by the immune-histological analysis. Assessment of the bio-distribution of contrast agents renders feasible. The cHSA-PEO (2000)₁₆-Gd has exhibited an improved specific tissue uptake by cancer cell xenografts and long lasting enhancement compared to traditional contrast agents.

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