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Abstract #2511

MR Microscopic Phenotyping of the Pancreas in Mutant KRas Mouse Models of Pancreatic Cancer

Palamadai N Venkatasubramanian1, Brian Hallis1, Matt Smith1, Emman Mascarinas2, Brian DeCant2, Andrew Diaz2, Ron McKinney2, Paul J Grippo2, and Alice M Wyrwicz1

1Radiology, NorthShore University HealthSystem, Evanston, IL, United States, 2Medicine, University of Illinois at Chicago, Chicago, IL, United States

The source, targeting and delivery of mutant Kras contribute to altered phenotypes of pancreatic cancer progression in mouse models of the disease. We have used multiparametric MR imaging including microscopy, diffusion imaging and T2 mapping, to capture differences in the MR characteristics of EL-Kras and p48-Cre/LSL-Kras mouse models of pancreatic cancer.

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