Abstract #2512

Glycerophosphocholine (GPC) Phosphodiesterases GDPD5 and GDPD6 are Essential for the Survival of Breast Cancer Cells

Menglin Cheng¹, Balaji Krishnamachary¹, Zaver M. Bhujwalla^1,2, Asif Rizwan¹, Lu Jiang¹, and Kristine Glunde^1,2

¹The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, United States

Glycerophosphocholine (GPC) is an important MRS-detected metabolite in choline metabolism of breast cancer. Transient silencing of the GPC-phosphodiesterases GDPD5 and GDPD6 increases ¹H or ³¹P MRS detectable GPC levels in breast cancer cells. Constitutive knockdown of GDPD5 or GDPD6 effectively kills MCF-7 and MDA-MB-231 breast cancer cells, but not nonmalignant MCF-12A breast epithelial cells, making GDPD5 and GDPD6 interesting theranostic targets whose knockdown or inhibition can be monitored by non-invasive MRS.

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