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Abstract #2512

Glycerophosphocholine (GPC) Phosphodiesterases GDPD5 and GDPD6 are Essential for the Survival of Breast Cancer Cells

Menglin Cheng1, Balaji Krishnamachary1, Zaver M. Bhujwalla1,2, Asif Rizwan1, Lu Jiang1, and Kristine Glunde1,2

1The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, United States

Glycerophosphocholine (GPC) is an important MRS-detected metabolite in choline metabolism of breast cancer. Transient silencing of the GPC-phosphodiesterases GDPD5 and GDPD6 increases 1H or 31P MRS detectable GPC levels in breast cancer cells. Constitutive knockdown of GDPD5 or GDPD6 effectively kills MCF-7 and MDA-MB-231 breast cancer cells, but not nonmalignant MCF-12A breast epithelial cells, making GDPD5 and GDPD6 interesting theranostic targets whose knockdown or inhibition can be monitored by non-invasive MRS.

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