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Abstract #2514

Implications of angiogenesis in glioma malignancies using C6 glioma model in Wistar and Sprague-Dawley (SD) rats

Nai-Wei Yao1, Chen-Tung Yen2, Jeou-Yuan Chen1, and Chen Chang1

1Institute of Biomedical Sciences, Academic Sinica, Taipei, Taiwan, 2Department of Life Science, National Taiwan University, Taipei, Taiwan

Angiogenesis is a well-known cancer hallmark, which dominates the prognosis and outcome of cancer patients. To establish rational treatment by targeting angiogenesis tailored to glioma patients, in this study, we examined the role of angiogenesis in the pathogenic development of glioma using rat C6 glioma models in Wistar and Sprague-Dawley (SD) rats. By immunohistochemistry and multi-parametric MRI methods, we show that C6 gliomas developed in the SD rats were characterized with enlarged tumors and with shorter survival. The increased tumor growth in SD rats was associated with increased angiogenesis, higher levels of HIF-1 and VEGF expression, and the polarization of the pro-tumorigenic M2 macrophages.

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