Abstract #2515

31P spectroscopic imaging for evaluation of early effects of photodynamic treatment on tumor metabolism

Tom Schreurs¹, Sophie Peereboom², Gustav Strijkers³, Jeanine Prompers¹, and Klaas Nicolay¹

¹Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, ²Biomedical Engineering, ETH Zürich, Zürich, Switzerland, ³Bioengineering and Physics, Academic Medical Center Amsterdam, Amsterdam, Netherlands

The feasibility of ³¹P spectroscopic imaging to evaluate effects of photodynamic therapy (PDT) on tumor metabolism was assessed. In PDT, a light-activated drug and local laser irradiation are used to ablate tumors. Spectroscopic imaging was used to visualize ATP and P_i after PDT in a mouse tumor model before, during, and up to 1 day after PDT. Treatment was performed inside the 9.4T scanner. Clear changes in phosphorus metabolite signals were already observed at 20 min after PDT, indicating a rapid decrease in energetic status. Moreover, the potential of spectroscopic imaging to detect spatial heterogeneities in these changes was demonstrated.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.