Abstract #2517

MRI for noninvasive characterization of pancreatic tumor in three mouse models

Navid Farr¹, Yak-Nam Wang², Samantha D’Andrea³, Kayla Gravelle³, Joo Ha Hwang^1,3, and Donghoon Lee⁴

¹Department of Bioengineering, University of Washington, Seattle, WA, United States, ²Applied Physics Laboratory, University of Washington, Seattle, WA, United States, ³Department of Medicine, University of Washington, Seattle, WA, United States, ⁴Department of Radiology, University of Washington, Seattle, WA, United States

The lethal nature of the pancreatic cancer is apparent in the 5-year survival rate of less than 5%. Choosing the right animal model is of utmost importance in oncology drug development research. There is a dire necessity for noninvasive techniques to monitor and characterize the tumors in different models to properly design drug delivery studies. We performed multi-parametric MRI at a high resolution to noninvasively identify the tumor and assess tumor volume characteristics. We used T1 and T2 relaxation, diffusion, and magnetization transfer effects along with 3 dimensional volume measurements. MR measurements were then compared with quantifiable histopathological results.

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