Abstract #2518

Differential metabolism of patient-derived renal tumor tissues using clinically translatable hyperpolarized 13C pyruvate

Renuka Sriram¹, Mark Van Criekinge¹, Justin Delos Santos¹, Kayvan R Keshari², Donna Peehl³, John Kurhanewicz¹, and Zhen Jane Wang¹

¹University of California, San Francisco, San Francisco, CA, United States, ²Memorial Sloan-Kettering Cancer Center, New York, NY, United States, ³Stanford University, Stanford, CA, United States

Management of renal cell carcinomas (RCCs) is reliant on imaging, which cannot reliably differentiate malignant RCCs from benign renal tumors. RCCs exhibit increased glycolysis, resulting in elevated lactate production. This can be used to differentiate RCCs from benign renal tumors using the hyperpolarized ¹³C MRI, a molecular imaging technique that can measure real-time dynamic pathway-specific metabolic fluxes. Our aim was to investigate the pyruvate-to-lactate flux in living patient-derived renal tissues using hyperpolarized [1-¹³C]pyruvate. We have shown that rapid lactate efflux is a distinguishing feature of clear cell RCCs (which comprise 90% of all RCCs), and can be detected using hyperpolarized [1-13C]pyruvate.

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