Differential metabolism of patient-derived renal tumor tissues using clinically translatable hyperpolarized 13C pyruvate
Renuka Sriram1, Mark Van Criekinge1, Justin Delos Santos1, Kayvan R Keshari2, Donna Peehl3, John Kurhanewicz1, and Zhen Jane Wang1
1University of California, San Francisco, San Francisco, CA, United States, 2Memorial Sloan-Kettering Cancer Center, New York, NY, United States, 3Stanford University, Stanford, CA, United States
of renal cell carcinomas (RCCs) is reliant on imaging, which cannot reliably differentiate malignant RCCs from benign renal tumors. RCCs
exhibit increased glycolysis, resulting in elevated lactate production. This can
be used to differentiate RCCs from benign renal tumors using the hyperpolarized
13C MRI, a molecular imaging technique that can measure real-time
dynamic pathway-specific metabolic fluxes. Our aim was to investigate the pyruvate-to-lactate
flux in living patient-derived renal tissues using hyperpolarized [1-13C]pyruvate.
We have shown that rapid lactate efflux is a distinguishing feature of clear
cell RCCs (which comprise 90% of all RCCs), and can be detected using hyperpolarized
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