Abstract #2519

Proton HR-MAS NMR Tissue metabolomic studies of non-muscle invasive Urinary Bladder Carcinoma

Abhinav Arun Sonkar¹, Yadvendra Dheer², Suruchi Singh³, Nuzhat Husain⁴, S N Shankhawar⁵, Apul Goel⁵, and Raja Roy³

¹Surgery, King George's Medical University, Lucknow, India, ²Paediatric Surgery, King George's Medical University, Lucknow, India, ³Centre for Biomedical Research, Sanjay Gandhi Post-Graduate Institute of Medical Sciences, Lucknow, India, ⁴Pathology, RMLIMS, Lucknow, India, ⁵Urology, King George's Medical University, Lucknow, India

In the present work, proton HR-MAS NMR spectroscopic studies of muscle non-invasive Urinary Bladder Carcinoma (UBC) tissue specimens have been performed. The detailed metabolic profile demonstrated significant presence of taurine in tissues of 27 patients suffering from superficial UBC. Same number of oher patients with benign tumors showed absence of taurine resonances in tissues. Taurine may be used as a fingerprint biomarker in conjunction with clinical and radiological findings, non-invasively in UBC.

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