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Abstract #2519

Proton HR-MAS NMR Tissue metabolomic studies of non-muscle invasive Urinary Bladder Carcinoma

Abhinav Arun Sonkar1, Yadvendra Dheer2, Suruchi Singh3, Nuzhat Husain4, S N Shankhawar5, Apul Goel5, and Raja Roy3

1Surgery, King George's Medical University, Lucknow, India, 2Paediatric Surgery, King George's Medical University, Lucknow, India, 3Centre for Biomedical Research, Sanjay Gandhi Post-Graduate Institute of Medical Sciences, Lucknow, India, 4Pathology, RMLIMS, Lucknow, India, 5Urology, King George's Medical University, Lucknow, India

In the present work, proton HR-MAS NMR spectroscopic studies of muscle non-invasive Urinary Bladder Carcinoma (UBC) tissue specimens have been performed. The detailed metabolic profile demonstrated significant presence of taurine in tissues of 27 patients suffering from superficial UBC. Same number of oher patients with benign tumors showed absence of taurine resonances in tissues. Taurine may be used as a fingerprint biomarker in conjunction with clinical and radiological findings, non-invasively in UBC.

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