Abstract #2523

Metabolomic studies of cancer cells and ascitic fluid in ovarian cancer models

Santosh Bharti¹, Flonne Wildes¹, Chien-Fu Hung², TC Wu², Zaver M Bhujwalla^1,3, and Marie-France Penet^1,3

¹JHU ICMIC Program, Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Baltimore, MD, United States, ²Pathology, The Johns Hopkins School of Medicine, Baltimore, MD, United States, ³Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School of Medicine, Baltimore, MD, United States

Epithelial ovarian cancer remains the leading cause of death from gynecologic malignancy among women in developed countries. A better understanding of the disease, and early detection are urgently needed to minimize morbidity, and to improve survival rates. High-resolution proton magnetic resonance spectroscopy (MRS) provides opportunities to characterize biofluid metabolite profiles for better characterization and improved detection of ovarian cancer. Here, we are investigating metabolites in ascites, cells and culture media of two different ovarian cancer models, and have detected significant differences in their metabolite profiles.

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